Efecto protector del entrenamiento físico aeróbico sobre el estrés oxidativo causado por material particulado en ratas
Resumen
Introducción: El material particulado (MP) es un contaminante del aire asociado con efectos nocivos para la salud. Estos efectos incluyen el estrés oxidativo, que puede ser el resultado de una respuesta inflamatoria local al daño sistémico del cuerpo. Algunos estudios indican que cuando el individuo se somete a in entrenamiento físico aeróbico, genera un efecto protector antioxidante que supera los efectos nocivos generados por el MP. Objetivo: Por lo tanto, el objetivo del estudio fue evaluar la influencia de las partículas MP2.5 y MP10 sobre el estrés oxidativo. Métodos: La evaluación de la influencia de la MP en los parámetros de estrés oxidativo se llevó a cabo utilizando superóxido dismutasa, catalasa, glutatión peroxidasa y niveles de antioxidantes totales en ratas Wistar machos no expuestas a partículas, con y sin entrenamiento aeróbico y expuesto a partículas MP2.5 y MP10, con y sin entrenamiento aeróbico. Resultados: Las enzimas antioxidantes analizadas que mostraron una diferencia significativa fueron catalasa y glutatión peroxidasa. Conclusiones: De esta investigación fue posible darse cuenta de que la MP influye negativamente en el estrés oxidativo y el peso corporal de las ratas y que el ejercicio aeróbico genera un efecto protector contra estos daños.
Referencias
Aebi, H. (1984). Catalase in vitro. Methods in Enzymology, 105, 121-7. Retrieved from: https://doi.org/10.1016/S0076-6879(84)05016-3
Arbex, M.A., Santos, U. de. P. Martins, L.C., Saldiva, P.H.N., Pereira, L.A.A., & Braga, A.L.F. (2012). A poluição do ar e o sistema respiratório. Jornal Brasileiro de Pneumologia, 38(5), 643-655. Retrieved from: https://doi.org/10.1590/S1806-37132012000500015
Banerjee, A.K., Mandal, A., Chanda, D., & Chakraborti, S. (2003). Oxidant, antioxidant and physical exercise. Molecular and cellular biochemistry, 253(1-2), 307-312. Retrieved from: https://doi.org/10.1023/A:1026034312124
Benzie, I.F., & Strain, J.J. (1996). The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Analytical biochemistry, 239(1), 70-76. Retrieved from: https://doi.org/10.1006/abio.1996.0292
Braga, A., Pereira, L.A.A., Böhm, G.M., & Saldiva, P. (2001). Poluição atmosférica e saúde humana. Revista USP, (51), 58-71. Retrieved from: https://doi.org/10.11606/issn.2316-9036.v0i51p58-71
Brook, R. D. (2008). Cardiovascular effects of air pollution. Clinical science, 115(6), 175-187. Retrieved from: https://doi.org/10.1042/CS20070444
Cançado, J.E.D., Braga, A., Pereira, L.A.A., Arbex, M.A., Saldiva, P.H.N., & Santos, U.D.P. (2006). Repercussões clínicas da exposição à poluição atmosférica. Jornal brasileiro de pneumologia, 32(Supl. 1), S5-S11. Retrieved from: https://doi.org/10.1590/S1806-37132006000800003
Castro, H.A. de, Gouveia, N., & Escamilla-Cejudo, J.A. (2003). Methodological issues of the research on the health effects of air pollution. Revista Brasileira de Epidemiologia, 6(2), 135-149. Retrieved from: https://doi.org/10.1590/S1415-790X2003000200007
Coelho, B.L. Rocha, L.G.C., Scarabelot, K.S., Scheffer, D.L., Ronsani, M.M., Silveira, P.C.L. et al. (2010). Physical exercise prevents the exacerbation of oxidative stress parameters in chronic kidney disease. Journal of Renal Nutrition, 20(3), 169-175. Retrieved from: https://doi.org/10.1053/j.jrn.2009.10.007
Dallarosa, J., Teixeira, E.C., Meira, l., & Wiegand, F. (2008). Study of the chemical elements and polycyclic aromatic hydrocarbons in atmospheric particles of PM10 and PM2. 5 in the urban and rural areas of South Brazil. Atmospheric Research, 89(1-2), 76-92. Retrieved from: https://doi.org/10.1016/j.atmosres.2007.12.004
Faraji, B., Kang, H.K., & Valentine, J.L. (1987). Methods compared for determining glutathione peroxidase activity in blood. Clinical chemistry, 33(4), 539-543. Retrieved from: https://doi.org/10.1093/clinchem/33.4.539
Fashi, M., Alinejad, H.A., & Mahabadi, H.A. (2015). The effect of aerobic exercise in ambient particulate matter on lung tissue inflammation and lung cancer. Iranian journal of cancer prevention, 8(3). Retrieved from: https://doi.org/10.17795/ijcp2333
Grochanke, B.S. (2015). Efeito da exposição crônica ao material particulado fino nos parâmetros de estresse oxidativo em pulmões de camundongos submetidos ao consumo de dieta hiperlipídica. Retrieved from: https://repositorio.ufcspa.edu.br/jspui/handle/123456789/151
Hoffman, J.B., Petriello, M.C., & Hennig, B. (2017). Impact of nutrition on pollutant toxicity: an update with new insights into epigenetic regulation. Reviews on environmental health, 32(1-2), 65-72. Retrieved from: https://doi.org/10.1515/reveh-2016-0041
Huttunen, K., Siponen, T., Salonen, I., Yli-Tuomi, T., Aurela, M., & Dufva, H. (2012). Low-level exposure to ambient particulate matter is associated with systemic inflammation in ischemic heart disease patients. Environmental research, 116, 44-51. Retrieved from: https://doi.org/10.1016/j.envres.2012.04.004
Institute of Laboratory Animal Resources, Commissions on Life Sciences, National Research Council (2003). The Guide for the Care and Use of Laboratory Animals. Association for Assessment and Accreditation of Laboratory Animal Care.
Kostrycki, I. M. (2016). Resposta anti-inflamatória do exercício físico agudo não ocorre em camundongos obesos expostos ao material particulado fino. Doctoral dissertation. Retrieved from: http://repositorio.ufcspa.edu.br/jspui/handle/123456789/311
Marmett, B. Nunes, R.B., Souza, K.S. de, Lago, P.D., & Rhoden, C.R. (2018). Aerobic training reduces oxidative stress in skeletal muscle of rats exposed to air pollution and supplemented with chromium picolinate. Redox Report, 23(1), 146-152. Retrieved from: https://doi.org/10.1080/13510002.2018.1475993
Martinelli, N., Olivieri, O., & Girelli, D. (2013). Air particulate matter and cardiovascular disease: a narrative review. European journal of internal medicine, 24(4), 295-302. Retrieved from: https://doi.org/10.1016/j.ejim.2013.04.001
Matt, F. Cole-Hunter, T., Donaire-Gonzalez, D., Kubesch, N., Martínez, D., & Carrasco-Turigas, D. (2016). Acute respiratory response to traffic-related air pollution during physical activity performance. Environment international, 97, 45-55. Retrieved from: https://doi.org/10.1016/j.envint.2016.10.011
National Research Council (2011). Guía para el cuidado y uso de animales de laboratorio. Chile: Ediciones UC.
Nesi, R.T., Souza, P.S. de, Santos, G.P. dos, Thirupathi, A., Menegali, B.T., Silveira, P.C.L. et al. (2016). Physical exercise is effective in preventing cigarette smoke-induced pulmonary oxidative response in mice. International journal of chronic obstructive pulmonary disease, 11, 603. Retrieved from: https://doi.org/10.2147/COPD.S93958
Osier, M., & Oberdörster, G. (1997). Intratracheal inhalation vs intratracheal instillation: differences in particle effects. Fundamental and Applied Toxicology, 40(2), 220-227. Retrieved from: https://doi.org/10.1093/toxsci/40.2.220
Pearson, J. F., Bachireddy, C., Shyamprasad, S., Goldfine, A.B., & Brownstein, J.S. (2010). Association between fine particulate matter and diabetes prevalence in the US. Diabetes care, 33(10), 2196-2201. Retrieved from: https://doi.org/10.2337/dc10-0698
Pleban, P. A., Munyani, A., & Beachum, J. (1982). Determination of selenium concentration and glutathione peroxidase activity in plasma and erythrocytes. Clinical Chemistry, 28(2), 311-316. Retrieved from: https://doi.org/10.1093/clinchem/28.2.311
Rao, X., Zhong, J., Brook, R.D., & Rajagopalan, S. (2018). Effect of particulate matter air pollution on cardiovascular oxidative stress pathways. Antioxidants & redox signaling, 28(9), 797-818. Retrieved from: https://doi.org/10.1089/ars.2017.7394
Rhoden, C. R., Lawrence, J., Godleski, J.J., & González-Flecha, B. (2004). N-acetylcysteine prevents lung inflammation after short-term inhalation exposure to concentrated ambient particles. Toxicological Sciences, 79(2), 296-303. Retrieved from: https://doi.org/10.1093/toxsci/kfh122
Samet, J.M., & Gruskin, S. (2015). Air pollution, health, and human rights. The Lancet Respiratory Medicine, 3(2), 98-100. Retrieved from: https://doi.org/10.1016/S2213-2600(14)70145-6
Silva, L.A., Ronsani, M.M., Souza, P.S., Severino, B.J., Fraga, D.B., & Streck, E.I. et al. (2010). Comparação do treinamento físico de quatro e oito semanas sobre atividade da cadeia transportadora de elétrons e marcadores de estresse oxidativo em fígado de camundongos. Revista brasileira de medicina do esporte, 16(2), 126-129. Retrieved from: http://dx.doi.org/10.1590/S1517-86922010000200010
Sorensen, M., Autrup, H., Møller, P., Hertel, O., Jensen, S.S., & Vinzents, P. (2003). Linking exposure to environmental pollutants with biological effects. Mutation Research/Reviews in Mutation Research, 544(2-3), 255-271. Retrieved from: https://doi.org/10.1016/j.mrrev.2003.06.010
Strak, M., Boogaard, H., Meliefste, K., Oldenwening, M., Zuurbier, M., & Brunekreef, B. et al. (2010). Respiratory health effects of ultrafine and fine particle exposure in cyclists. Occupational and environmental medicine, 67(2), 118-124. Retrieved from: http://dx.doi.org/10.1136/oem.2009.046847
Vollaard, N. B., Shearman, J.P., & Cooper, C.E. (2005). Exercise-induced oxidative stress. Sports medicine, 35(12), 1045-1062. Retrieved from: https://doi.org/10.2165/00007256-200535120-00004
WHO Europe (2013). World Health Organization. Health effects of particulate matter. Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK361805/
Wong, J. (2016). Lung inflammation caused by inhaled toxicants: a review. International journal of chronic obstructive pulmonary disease, 11, 1391. Retrieved from: https://doi.org/10.2147/COPD.S106009
Yuan, X., Wang, Y., Li, L., Zhou, W., Tian, D. & Lu, D. et al. (2016). PM 2.5 induces embryonic growth retardation: Potential involvement of ROS-MAPKs-apoptosis and G0/G1 arrest pathways. Environmental toxicology, 31(12), 2028-2044. Retrieved from: https://doi.org/10.1002/tox.22203
Zhou, W., Tian, D., He, J., Zhang, L., Tang, X., Zhang, L. et al. (2017). Exposure scenario: another important factor determining the toxic effects of PM2.5 and possible mechanisms involved. Environmental pollution, 226, 412-425. Retrieved from: https://doi.org/10.1016/j.envpol.2017.04.010
Derechos de autor 2020 Lecturas: Educación Física y Deportes
Esta obra está bajo licencia internacional Creative Commons Reconocimiento-NoComercial-SinObrasDerivadas 4.0.
