Influence of amphokinase gene C34T mutation in coronary disease and exercise

Abstract

The Adenosonine Monophosphate Deaminase (AMPD) is present in short duration intense muscular contractions. It’s role is to minimize the ADP rush on muscle. This enzyme is located at the cromossome 1p13-p21 and it’s isoform M can be activated after a strong skeletal muscle contraction. Individuals that presents the polypeptidic mutant sequence, homozygous TT or heterozygous CT shows, respectively, less and medium enzymatic activity of mioadenylate deaminase compared to homozygous CC individuals. A bibliographic research was accomplished on the virtual databases Scielo, PubMed and ScienceDirect. Using the keywords AMP deaminase, cardiac disease, skeletal muscle, physical exercise and polymorphism. This review had the objective of showing the value of the AMPD polymorphism on coronary disease prevention on people with tendentious alleles that can soften its symptoms and prevent aerobic performance loss during the treatment and for high performance in sports. Where we can use the genetic tests to identify potential talents for power sports with the presence of the homozygous CC and heterozygous CT.