Effects of Exercise on the Immune System, Cancer and COVID-19: An Integrative Review

Abstract

Investigating up-to-date scientific information of the effects of physical exercise on the immune system, cancer and COVID-19 is the objective of this review. Method: an integrative review using as keywords: immunology, physical exercise, cancer, and COVID. The search took place between May 4, 2020, and July 31, 2020, on the Capes Portal, in the databases: Scielo, Medline, Lilacs, Pubmed, Science Direct and Bireme and the Google Scholar search engine, corresponding to the period between 2000 and 2020. The studies were classified by the subject company, peer-reviewed, in the languages: Portuguese, Spanish, Italian, and English. The inclusion criteria for articles, randomized clinical trial, systematic review, bibliographic review, book chapters, research experimental, and scientific chart investigating the effects of physical exercise on the immune system and cancer were used, and exclusion criteria were studies focused exclusively on nutritional, dental, and psychological aspects. Results: using the terms Immunology AND Physical Exercise AND Cancer, 1637 articles were found; when used: Immunology OR Physical Exercise AND Cancer, 8535 articles were found. When the term COVID was inserted, only 4 articles were found. For theoretical foundation, the 24 (twenty-four) most relevant publications were selected. Conclusions: the immune system is certainly stimulated by exercises of light and moderate intensity, and vigorous exercises effective to improve coping with cancer. Regular physical exercise should be encouraged in asymptomatic individuals from COVID-19. Immobility should be avoided, due to the risk of venous thromboembolism (VTE).

Keywords: Cancer, Immunology, Immunity, Exercice, COVID-19

References

Anzeneder, S., Benzing, V. J., Pompei, L., & Schmidt, M. (2020). Physical and mental health outcomes of physical exercise training in young cancer inpatients and survivors-a systematic review of RCTs. Kind, Sport und Gesundheit, 12. SGS-Jahrestagung. Basel. Recuperado de: https://doi.org/10.7892/boris.144444

Campbell, K. L., Zadravec, K., Bland, K. A., Chesley, E., Wolf, F., & Janelsins, M. C. (2020). The Effect of Exercise on Cancer-Related Cognitive Impairment and Applications for Physical Therapy: Systematic Review of Randomized Controlled Trials. Physical Therapy, 100(3), 523-542. Recuperado de: https://doi.org/10.1093/ptj/pzz090

Cataldi, S., Greco, G., Mauro, M., & Fischetti, F. (2020). Effect of exercise on cancer-related fatigue: A systematic review. Journal of Human Sport and Exercise,16(3). Recuperado de: https://doi.org/10.14198/jhse.2021.163.01

Crossetti, M. D. G. O. (2012). Revisão integrativa de pesquisa na enfermagem: o rigor científico que lhe é exigido. Revista gaúcha de enfermagem, 33(2), 08-09. Recuperado de: https://doi.org/10.1590/S1983-14472012000200001

Del-Rosal-Jurado, A., Romero-Galisteo, R., Trinidad-Fernández, M., González-Sánchez, M., Cuesta-Vargas, A., & Ruiz-Muñoz, M. (2020). Therapeutic Physical Exercise Post-Treatment in Breast Cancer: A Systematic Review of Clinical Practice Guidelines. Journal of Clinical Medicine, 9(4), 1239. Recuperado de: https://doi.org/10.3390/jcm9041239

Demirci, U., Ozdemir, H., Demirbag-Kabayel, D., Umit, E.G., & Demir, A.M. (2020). Reducing the Risk of Venous Thrombosis During Self-Isolation and COVID-19 Pandemic for Patients with Cancer: Focus on Home Exercises Prescription. Clin Appl Thromb Hemost , 26. Recuperado de: https://doi.org/10.1177/1076029620933947

Duarte, D. A., & Brandão, D. (2010). Achados Sobre a Influência do Exercício Físico na Fisiologia Imunitária. Revista Eletrônica Acervo Saúde,1,10-18. Recuperado de: https://www.acervosaude.com.br/doc/artigo_004.pdf

Duarte, D. A., & de Melo-Almeida, M. G. (2010). Aspectos Moleculares do Sistema Imunológico no Envelhecimento. Revista Eletrônica Acervo Saúde,1,1-10. Recuperado de: https://www.acervosaude.com.br/doc/artigo_003.pdf

Ferreira, C. K. O., Prestes, J., Donatto, F. F., Vieira, W. H. B., Palanch, A. C., & Cavaglieri, C. R. (2007). Efeitos agudos do exercício de curta duração sobre a capacidade fagocitária de macrófagos peritoneais em ratos sedentários. Brazilian Journal of Physical Therapy, 11(3), 191-197. Recuperado de: http://dx.doi.org/10.1590/S1413-35552007000300004

Guo, Y., Xu, M., Wei, Z., Hu, Q., Chen, Y., Yan, J., & Wei, Y. (2018). Beneficial effects of qigong wuqinxi in the improvement of health condition, prevention, and treatment of chronic diseases: Evidence from a systematic review. Evidence-Based Complementary and Alternative Medicine. Recuperado de: http://dx.doi.org/10.1155/2018/3235950

Henriques, I., Cebola, M., Mendes, L. (2020). Malnutrition, Sarcopenia and COVID-19 in the Elderly: Scientific evidence for vitamin D supplementation. Acta Portuguesa de Nutrição, 21, 26-30. Recuperado de: https://dx.doi.org/10.21011/apn.2020.2106

Hyatt, A., Gough, K., Murnane, A., Au-Yeung, G., Dawson, T., Pearson, E. et al. (2020). i-Move, a personalised exercise intervention for patients with advanced melanoma receiving immunotherapy: a randomised feasibility trial protocol. BMJ open, 10(2), e036059. Recuperado de: http://dx.doi.org/10.1136/bmjopen-2019-036059

Koch, A.J. (2010). Immune response to resistance exercise. American Journal of Lifestyle Medicine, 4(3), 244-252. Recuperado de: http://dx.doi.org/10.1177/1559827609360190

Kufel-Grabowska, J., Marszalek, S., Gorecki, M., Malinowska, M., Lesiak, M., Straburzynska-Migaj, E. et al. (2020). Abstract P4-14-10: Supervised high intensity interval physical exercise of young women with breast cancer during neoadjuvant chemotherapy has also a positive impact on the control group (SPORT NATHY trial). Cancer Research, 80(4). Recuperado de: http://dx.doi.org/10.1158/1538-7445.SABCS19-P4-14-10

Leandro, C., Nascimento, E. D., Manhães-de-Castro, R., Duarte, J. A., & De-Castro, C. M. M. B. (2002). Exercício físico e sistema imunológico: mecanismos e integrações. Revista portuguesa de ciências do desporto, 2(5), 80-90. Recuperado de: http://dx.doi.org/:10.5628/rpcd.02.05.80

Leandro, C. G., Castro, R. M. D., Nascimento, E., Pithon-Curi, T. C., & Curi, R. (2007). Mecanismos adaptativos do sistema imunológico em resposta ao treinamento físico. Revista Brasileira de Medicina do Esporte, 13(5), 343-348. Recuperado de: http://dx.doi.org/:10.1590/S1517-86922007000500012

Martínez, A. C., & Alvarez-Mon, M. (1999). O sistema imunológico (I): Conceitos gerais, adaptação ao exercício físico e implicações clínicas. Revista Brasileira de Medicina do Esporte, 5(3), 120-125. Recuperado de: http://dx.doi.org/:10.1590/S1517-86921999000300010

Michael, M., Goble, J., Hawk, M., & Kujawa, D. J. (2020). Reported Barriers Impeding Adherence to a Physical Exercise Program in Patients with Breast Cancer: A Systematic Review. Rehabilitation Oncology. Recuperado de: http://dx.doi.org/10.1097/01.REO.0000000000000220

Morielli, A. R., & Courneya, K. S. (2020). Effects of Exercise on Cancer Treatment Completion and Efficacy. In Exercise Oncology (209-227). Springer, Cham. Recuperado de: http://dx.doi.org/10.1007/978-3-030-42011-6_10

Pescatello L.S. (ed.) (2014). American College of Sports Medicine Resource Manual for Guidelines for Exercise Testing and Prescription (9th ed.). Philadelphia: Lippincott Williams & Wilkins.

Regis, G., & Ganzit, G.P. (2020). Attività ginnico-sportiva: i benefici sulla salute in periodo di emergenza CoViD-19. Come organizzare una rapida ripresa / Gymnastics-sports activities: health benefits in emergency period CoViD-19. How to organize a quick shot. Recenti Prog Med, 111(5), 297-301. Recuperado de: https://doi.org/10.1701/3366.33411

Reis, S. C. (2019). O Exercício Físico Como Ativador do Sistema Imunológico-In: E-Book-Patologias e as novas perspectivas terapêuticas. Revista Artigos.com, 1, e442-capítulo. Recuperado de: https://doi.org/10.25248/e-book1.cap2.2019

Reis, S. C., & Duarte, D. A. (2018). O papel do exercício físico na ativação de células mononucleares do Sistema Imunológico. Revista Eletrônica Acervo Científico, 1, 49-57. Recuperado de: http://dx.doi.org/10.25248/REAC26

Shetty, S. S., Rao, V., Kudpaje, A., Mithra, S., Merchant, Y., & Shabadi, N. (2020). An oncologist perspective on COVID 19: A mysterious cryptic virus. Oral Oncology, 105. Recuperado de: http://dx.doi.org/10.1016/j.oraloncology.2020.104694

Sochart, D.H., & Hardinge, K. (1999). The relationship of foot and ankle movements to venous return in the lower limb. J Bone Joint Surg Br, 81(4), 700-704. Recuperado de: http://dx.doi.org/10.1302/0301-620X.81B4.8909

Todo-Bom, A., & Mota-Pinto, A. (2007). Exercício físico: resposta imunoinflamatória. Rev Port Imunoalergologia, 15 (2): 123-133. Recuperado de: http://hdl.handle.net/10400.4/778

Tsang, H. W., Mok, C. K., Au Yeung, Y. T., & Chan, S. Y. (2003). The effect of Qigong on general and psychosocial health of elderly with chronic physical illnesses: a randomized clinical trial. International journal of geriatric psychiatry, 18(5), 441-449. Recuperado de: https://doi.org/10.1002/gps.861

Vallerand, James R., Rhodes, Ryan E., Walker, Gordan J., & Courneya, Kerry S. (2019). Social Cognitive Effects and Mediators of a Pilot Telephone Counseling Intervention to Increase Aerobic Exercise in Hematologic Cancer Survivors. J Phys Act Health, 16(1), 43-51. Recuperado de: https://doi.org/10.1123/jpah.2018-0014

Vulczak, A., Souza, A. D. O., Ferrari, G. D., Azzolini, A. E. C. S., Pereira-da-Silva, G., & Alberici, L. C. (2020). Moderate Exercise Modulates Tumor Metabolism of Triple-Negative Breast Cancer. Cells, 9(3), 628. Recuperado de: http://dx.doi.org/10.3390/cells9030628

Wang, X., Pi, Y., Chen, B., Chen, P., Liu, Y., Wang, R. et al. (2015). Effect of traditional Chinese exercise on the quality of life and depression for chronic diseases: a meta-analysis of randomised trials. Scientific reports, 5(1), 1-16. Recuperado de: http://doi.org/10.1038/srep15913

Wen, J., Lin, T., Jiang, C., Peng, R., & Wu, W. (2017). Effect of Baduanjin exercises on elevated blood lipid levels of middle-aged and elderly individuals: protocol for a systematic review and meta-analysis of randomised controlled trials. BMJ open, 7(9), e017213. Recuperado de: http://dx.doi.org/10.1136/bmjopen-2017-017213

Wiggenraad, F., Bolam, K. A., Mijwel, S., van der Wall, E., Wengström, Y., & Altena, R. (2020). Long-Term Favourable Effects of Physical Exercise on Burdensome Symptoms in the OptiTrain Breast Cancer Randomized Controlled Trial. Integrative Cancer Therapies, 19. Recuperado de: http://dx.doi.org/10.1177/1534735420905003

Xiao, C. M., & Zhuang, Y. C. (2015). Efficacy of Liuzijue Qigong in individuals with chronic obstructive pulmonary disease in remission. Journal of the American Geriatrics Society, 63(7), 1420-1425. Recuperado de: http://dx.doi.org/10.1111/jgs.13478

Yao, L. Q., Tan, J. Y., Turner, C., Wang, T., & Liu, X. L. (2020). Traditional Chinese exercise for cancer-related sleep disturbance: A systematic review and descriptive analysis of randomized controlled trials. Complementary Therapies in Clinical Practice. Recuperado de: http://dx.doi.org/10.1016/j.ctcp.2020.101197

Ye, Q. (2014). Clinical Studies of Yijinjing Intervention to the Elderly. Hyperlipidemia [dissertation]. Nanjing University of Traditional Chinese Medicine, Nanjing. Recuperado de: https://doi.org/10.1016/j.ctcp.2020.101197

Published
2021-01-11
How to Cite
Oliveira, E. M. de, & Benetti, M. (2021). Effects of Exercise on the Immune System, Cancer and COVID-19: An Integrative Review. Lecturas: Educación Física Y Deportes, 25(272), 65-80. https://doi.org/10.46642/efd.v25i272.2518
Section
Review Articles