Cardiac Rehabilitation in Severe Sarcopenia: A Case Study

Abstract

Introduction: Sarcopenia is a multifactorial and systemic muscle disease characterized by progressive loss of muscle strength and mass, which impacts functionality, increases the risk of frailty, and long-term mortality. Cardiac surgery is known to cause a systemic inflammatory response associated with sarcopenia. Objective: To report and evaluate the efficacy of a cardiac rehabilitation program (Phase 2) in a patient with severe sarcopenia after coronary artery bypass graft surgery at the Cardiac Rehabilitation Service of the University Hospital of Santa Maria, Rio Grande do Sul, Brazil. Method: This is a case study of a 63-year-old male patient diagnosed with severe sarcopenia during a cardiac rehabilitation program. The outcomes evaluated were: functional capacity (six-minute walk test), muscle thickness (ultrasound), peripheral muscle endurance (handgrip strength and 1-minute sit-to-stand test), and quality of life (Minnesota Living with Heart Failure Questionnaire). Results: The patient was enrolled in the program, consisting of aerobic and resistance exercise combined with functional electrical stimulation, performed twice a week for 12 weeks. After completion, there was an improvement in all outcomes, demonstrating the effectiveness of the rehabilitation program. Conclusion: The findings confirm the effectiveness of cardiac rehabilitation in patients with severe sarcopenia after cardiac surgery, as well as demonstrating the importance of early screening and intervention for this condition, even in non-elderly patients, in the cardiac rehabilitation setting.

Keywords: Case report, Cardiac rehabilitation, Sarcopenia

References

ABESO (2009). Diretrizes brasileiras de obesidade 2009/2010 (3ª ed.). Associação Brasileira para o Estudo da Obesidade e Síndrome Metabólica.

Alves, I.G.N., Silva, C.M. da S., Martinez, B.P., Queiroz, R.S. de, e Gomez-Neto, M. (2022). Effects of neuromuscular electrical stimulation on exercise capacity, muscle strength, and quality of life in COPD patients: A systematic review with meta-analysis. Clinical Rehabilitation, 36(4), 449-471. https://doi.org/10.1177/02692155211067983

Amaral, J.F., Mancini, M., e Novo Junior, J.M. (2012). Comparison of three hand dynamometers in relation to the accuracy and precision of the measurements. Revista Brasileira de Fisioterapia, 16(3). https://doi.org/10.1590/s1413-35552012000300007

American Thoracic Society (2002). ATS statement: Guidelines for the six-minute walk test. American Journal of Respiratory and Critical Care Medicine, 166(1), 111-117. https://doi.org/10.1164/ajrccm.166.1.at1102

Ansaripour, A., Arjomandi Rad, A., Koulouroudias, M., Angouras, D., Athanasiou, T., e Kourliouros, A. (2023). Sarcopenia adversely affects outcomes following cardiac surgery: A systematic review and meta-analysis. Journal of Clinical Medicine, 12(17), 5573. https://doi.org/10.3390/jcm12175573

Bielecka-Dabrowa, A., Ebner, N., Dos Santos, M. R., Ishida, J., Hasenfuss, G., e von Haehling, S. (2020). Cachexia, muscle wasting, and frailty in cardiovascular disease. European Journal of Heart Failure, 22(12), 2314-2326. https://doi.org/10.1002/ejhf.2011

Bohannon, R.W., e Crouch, R. (2019). 1-Minute sit-to-stand test: Systematic review of procedures, performance, and clinimetric properties. Journal of Cardiopulmonary Rehabilitation and Prevention, 39(1), 2-8. https://doi.org/10.1097/hcr.0000000000000336

Britto, RR, Probst, VS, Andrade, AFD, Samora, GAR, Hernandes, NA, Marinho, PEM, Karsten, M., Pitta, F., e Parreira, VP (2013). Reference equations for the six-minute walk distance based on a Brazilian multicenter study. Brazilian Journal of Physical Therapy, 17(6), 556-563. https://doi.org/10.1590/s1413-35552012005000122

Champaiboon, J., Petchlorlian, A., e Manasvanich, B. (2023). Calf circumference as a screening tool for low skeletal muscle mass: Cut-off values in independent Thai older adults. BMC Geriatrics, 23, 826. https://doi.org/10.1186/s12877-023-04543-4

Carvalho, V.O., Guimarães, G.V., Carrara, D., Bacal, F., e Bocchi, E.A. (2009). Validação da versão em português do Minnesota Living with Heart Failure Questionnaire. Arquivos Brasileiros de Cardiologia, 93(1), 39-44. https://doi.org/10.1590/S0066-782X2009000700008

Cruz-Jentoft, AJ, Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, AA, Schneider, SM, Sieber, CC, Topinkova, E., Vandewoude, M., Visser, M., Zamboni, M., e Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2 (2019). Sarcopenia: Revised European consensus on definition and diagnosis. Age and Ageing, 48(1), 16-31. https://doi.org/10.1093/ageing/afy169

Damluji, AA., Alfaraidhy, M., AlHajri, N., Rohant, NN, Kumar, M., Malouf, CA, Bahrainy, S., Kwak, MJ, Batchelor, WB, Forman, DE, Rich, MW, Kirkpatrick, J., Krishnaswami, A., Alexander, KP, Gerstenblith, G., Cawthon, P., deFilippi, CR, e Goyal, P. (2023). Sarcopenia and cardiovascular diseases. Circulation, 147(20), 1534-1553. https://doi.org/10.1161/circulationaha.123.064071

Fivez, T., Hendrickx, A., Van Herpe, T., Vlasselaers, D., Desmet, L., Van den Berghe, G., e Mesotten, D. (2016). An analysis of reliability and accuracy of muscle thickness ultrasonography in critically ill children and adults. Journal of Parenteral and Enteral Nutrition, 40(7), 944-949. https://doi.org/10.1177/0148607115575033

Francis, C.A., Hoffer, J.A., e Reynolds, S. (2016). Ultrasonographic evaluation of diaphragm thickness during mechanical ventilation in intensive care patients. American Journal of Critical Care, 25(1). https://doi.org/10.4037/ajcc2016563

Furlanetto, K.C., Correia, NS, Mesquita, R., Morita, AA, Amaral, DP, Mont'Alverne, DGB, Pereira, DM, Pitta, F., e Dal Corso, S. (2022). Reference values for 7 different protocols of simple functional tests: A multicenter study. Archives of Physical Medicine and Rehabilitation, 103(5), 20-28. https://doi.org/10.1016/j.apmr.2021.08.009

Gonzalez-Saenz de Tejada, M., Bilbao, A., Ansola, L., Quirós, R., García-Perez, L., Navarro, G., e Escobar, A. (2019). Responsiveness and minimal clinically important difference of the Minnesota Living with Heart Failure Questionnaire. Health and Quality of Life Outcomes, 17(1), 36. https://doi.org/10.1186/s12955-019-1104-2

Gonzatti, N., Castagna, L., Carvalho, M.T.X., Santos, T.D., Cardoso, D.M., e Callegaro, C.C. (2021). Estimulação elétrica funcional associada ao treinamento combinado pós-CRM: Ensaio clínico randomizado. Fisioterapia em Movimento, 28(1), 101-108. https://doi.org/10.1590/1809-2950/20031628012021

Gremeaux, V., Troisgros, O., Benaïm, S., Hannequin, A., Laurent, Y., Casillas, JM, e Benaïm, C. (2011). Determining the minimal clinically important difference for the six-minute walk test and the 200-meter fast-walk test during cardiac rehabilitation program in coronary artery disease patients after acute coronary syndrome. Archives of Physical Medicine and Rehabilitation, 92(4), 611-619. https://doi.org/10.1016/j.apmr.2010.11.023

Herdy, A. H., López-Jimenez, F., Terzic, C. P., Milani, M., Stein, R., Carvalho, T., Serra, S., Araujo, CG, Zeballos, PC, Anchique, CV, Burdiat, GB, González, K., González, G., Fernández, R., Santibáñez, C., Rodríguez-Escudero, JP, e Ilarraza-Lomelí, H. (2014). South American guidelines for cardiovascular disease prevention and rehabilitation. Arquivos Brasileiros de Cardiologia, 103(2), 1-31. https://doi.org/10.5935/abc.2014s003

Hermes, BM, Cardoso, DM, Gomes, TJN, Santos, TD, Vicente, MS, Pereira, SN, Barbosa, VA, e Albuquerque, IM (2015). Short-term inspiratory muscle training potentiates the benefits of aerobic and resistance training in patients undergoing CABG in phase II cardiac rehabilitation program. Revista Brasileira de Cirurgia Cardiovascular, 30(4), 474-481. https://doi.org/10.5935/1678-9741.20150043

Hollingworth, T.W., Oke, S.M., Patel, H., e Smith, T.R. (2021). Getting to grips with sarcopenia: Recent advances and practical management for the gastroenterologist. Frontline Gastroenterology, 12(1), 53-61. https://doi.org/10.1136/flgastro-2019-101348

Iida, Y., Yamazaki, T., Arima, H., Kawabe, T., e Yamada, S. (2016). Predictors of surgery-induced muscle proteolysis in patients undergoing cardiac surgery. Journal of Cardiology, 68(6), 536-541. https://doi.org/10.1016/j.jjcc.2015.11.011

International Society for the Advancement of Kinanthropometry (ISAK). (2011). International standards for anthropometric assessment. Lower Hutt.

Kamyia, K., Hamazaki, N., Matsuzawa, R., Nozaki, K., Tanaka, S., Ichinosawa, Y., Maekawa, E., Noda, C., Yamaoka-Tojo, M., Matsunaga, A., Masuda, T., e Ako, J. (2017). Sarcopenia: Prevalence and prognostic implications in elderly patients with cardiovascular disease. JCSM Clinical Reports, 2, 1-13. https://doi.org/10.17987/jcsm-cr.v2i2.41

Mack, M. J., Squiers, J.J., Lytle, B.W., DiMaio, J.M., e Mohr, F.W. (2021). Myocardial revascularization surgery: JACC historical breakthroughs in perspective. Journal of the American College of Cardiology, 78(4), 365-383. https://doi.org/10.1016/j.jacc.2021.04.099

Mirzai, S., Eck, B.L., Chen, P.H., e Estep, J.D. (2022). Current approach to the diagnosis of sarcopenia in heart failure: A narrative review on the role of clinical and imaging assessments. Circulation: Heart Failure, 15, e009322. https://doi.org/10.1161/circheartfailure.121.009322

Novaes, R.D., Miranda, A.S. de, Silva, J. de O., Tavares, B.V.F., e Dourado, V.Z. (2009). Equações de referência para a predição da força de preensão manual em brasileiros de meia idade e idosos. Fisioterapia e Pesquisa, 16(3), 217-222. https://doi.org/10.1590/S1809-29502009000300005

Nunes, J.D., Zacarin, J. de F., Pavarini, S.C.I., Zazzetta, M.S., Orlandi, A.A. dos S., e Orlandi, F. de S. (2021). Fatores associados à sarcopenia em idosos da comunidade. Fisioterapia em Pesquisa, 28(2), 159-165. https://doi.org/10.1590/1809-2950/20002828022021

Okamura, H., Kimura, N., Mieno, M., Yuri, K., e Yamaguchi, A. (2020). Preoperative sarcopenia is associated with late mortality after off-pump coronary artery bypass grafting. European Journal of Cardio-Thoracic Surgery, 58(1), 121-129. https://pubmed.ncbi.nlm.nih.gov/31995164/

Park, S., Park, SH, Lee, J., Choi, YJ, Kang, DO, Park, EJ, Choi, JY, Roh, SY, Lee, DI, Na, JO, Kim, JW, Kim, EJ, Rha, SW, Park, CG, e Choi, CU (2025). Association of handgrip strength with readmission, mortality, and exercise capacity in patients with heart failure. Journal of Aging and Physical Activity, 1-11. https://doi.org/10.1123/japa.2023-0298

Pontes, V.C.B. (2022). Sarcopenia: Rastreio, diagnóstico e manejo clínico. Journal of Hospital Sciences, 2(1), 4-14. https://jhsc.emnuvens.com.br/revista/article/view/32

Sabatino, A., Kooman, J., Avesani, CM, Gregorini, M., Bianchi, S., Regolisti, G., e Fiaccadori, E. (2024). Sarcopenia diagnosed by ultrasound-assessed quadriceps muscle thickness and handgrip strength predicts mortality in patients on hemodialysis. Journal of Nephrology, 37(4), 993-1003. https://doi.org/10.1007/s40620-023-01867-7

Steinmetz, C., Krause, L., Sulejmanovic, S., Kaumkötter, S., Mengden, T., Grefe, C., Knoglinger, E., Reiss, N., Brixius, K., Bjarnason-Wehrens, B., Schmidt, T., von Haehling, S., Sadlonova, M., von Arnim, CAF, e Heinemann, S. (2024). The prevalence and impact of sarcopenia in older cardiac patients undergoing inpatient cardiac rehabilitation-results from a prospective, observational cohort pre-study. BMC Geriatrics, 24(1), 94. https://doi.org/10.1186/s12877-024-04694-y

Tanriverdi, A., Kahraman, B.O., Ozpelit, E., e Savci, S. (2023). Test-retest reliability and validity of 1-minute sit-to-stand test in patients with chronic heart failure. Heart, Lung and Circulation, 32(4), 518-524. https://doi.org/10.1016/j.hlc.2023.01.008

Tomassini, S., Abbasciano, R., e Murphy, G.J. (2021). Interventions to prevent and treat sarcopenia in a surgical population: A systematic review and meta-analysis. BJS Open, 5(3), zraa069. https://doi.org/10.1093/bjsopen/zraa069

Van Venrooij, L.M., Verberne, H.J., de Vos, R., Borgmeijer-Hoelen, M.M., van Leeuwen, P.A., e de Mol, B.A. (2012). Postoperative loss of skeletal muscle mass, complications, and quality of life in patients undergoing cardiac surgery. Nutrition, 28(1), 40-45. https://doi.org/10.1016/j.nut.2011.02.007

Viana, J.U., Dias, J.M.D., Pereira, L.S.M., Silva, S.L.A. da, Hoezle, L.F., e Dias, R.C. (2018). Pontos de corte alternativos para massa muscular apendicular para verificação da sarcopenia em idosos brasileiros: Dados da Rede Fibra - Belo Horizonte/Brasil. Fisioterapia em Pesquisa, 25, 166-172. https://doi.org/10.1590/1809-2950/17533725022018

Yuenyongchaiwat, K., Kulchanarat, C., e Satdhabudha, O. (2020). Sarcopenia in open heart surgery patients: A cohort study. Heliyon, 6(12), e05759. https://doi.org/10.1016/j.heliyon.2020.e05759

Zeng, Q., Zhao, L., Zhong, Q., An, Z., e Li, S. (2024). Changes in sarcopenia and incident cardiovascular disease in prospective cohorts. BMC Medicine, 22(1), 607. https://doi.org/10.1186/s12916-024-03841-x

Author Biographies

Rafaela Bassan Bortoluzzi,

http://lattes.cnpq.br/4500454602335511

Viviane Bohrer Berni,

http://lattes.cnpq.br/8487833467152552

Marlusse Silveira,

http://lattes.cnpq.br/7717271215703495

Isabella Martins de Albuquerque,

http://lattes.cnpq.br/5579735303815692

Published
2025-08-30
How to Cite
Bortoluzzi, R. B., Berni, V. B., Silveira, M., & Albuquerque, I. M. de. (2025). Cardiac Rehabilitation in Severe Sarcopenia: A Case Study. Lecturas: Educación Física Y Deportes, 30(328), 164-177. https://doi.org/10.46642/efd.v30i328.8374
Section
Case Study (Clinical)